Description

(R)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid is a high-purity, non-natural amino acid derivative featuring a morpholine ring and a Boc-protected amine group, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized chemical probes. The CAS number for this compound is 788819-12-5.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and other small-molecule drugs.
• Peptidomimetics Synthesis: Used to incorporate the morpholine moiety into peptide backbones, enhancing metabolic stability and modifying pharmacological properties.
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged compounds used in studying biological pathways and target engagement.
• Asymmetric Catalysis Ligand Precursor: The chiral center and heteroatoms make it a potential precursor for synthesizing novel ligands used in asymmetric synthesis.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(R)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid
CAS No.	788819-12-5
Molecular Formula	C12H22N2O5
Molecular Weight	274.32 g/mol
Synonyms	Boc-D-Morpholinoglycine; (R)-2-((tert-Butoxycarbonyl)amino)-3-morpholine-4-ylpropanoic acid; Boc-D-MorGly-OH; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3-morpholin-4-ylpropanoic acid; (R)-3-Morpholino-2-((tert-butoxycarbonyl)amino)propanoic acid; D-Boc-3-morpholinylalanine; Boc-D-3-(4-Morpholinyl)alanine; N-Boc-D-3-morpholinylalanine
EINECS	Contact for details

Quality Control

Our (R)-2-((tert-Butoxycarbonyl)Amino)-3-Morpholinopropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and residual solvent content. Our quality commitment supports applications in cGMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.