Description

Doxepin Glucuronide (Mixture Of Z And E Isomers) CAS NO 788790-52-3 is a key glucuronide metabolite of the tricyclic antidepressant doxepin. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and impurity profiling to ensure drug safety and regulatory compliance.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of doxepin and its metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and exposure levels of doxepin in preclinical and clinical research.
• Impurity Profiling and Characterization: Used to identify, quantify, and monitor this specific glucuronide conjugate as a potential impurity in active pharmaceutical ingredient (API) batches of doxepin.
• Pharmacology and Toxicology Research: Supports studies aimed at understanding the activity, distribution, and potential toxicity of doxepin metabolites.
• Regulatory Submission Support: Provides essential data for regulatory filings (e.g., with the FDA, EMA) by enabling accurate metabolite reporting and safety assessments.
• Method Development and Validation: Acts as a benchmark compound for developing, optimizing, and validating robust analytical methods in compliance with ICH guidelines.

Basic Information

Item	Details
Product Name	Doxepin Glucuronide (Mixture Of Z And E Isomers)
CAS No.	788790-52-3
Molecular Formula	C25H30N2O7
Molecular Weight	470.52 g/mol
Synonyms	Doxepin Glucuronide; Doxepin N-Glucuronide; Doxepin Metabolite Glucuronide; (3E)-3-(6H-Benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-1-propanamine Glucuronide; (3Z)-3-(6H-Benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethyl-1-propanamine Glucuronide; Doxepin O-Glucuronide (isomer-specific); Doxepin Glucuronide Isomers; Doxepin Major Metabolite
EINECS	Contact for details

Quality Control

Every batch of Doxepin Glucuronide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and stability testing using advanced analytical techniques such as HPLC, LC-MS, and NMR to ensure compliance with the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA), detailing batch-specific results including isomeric ratio, assay, and impurity profiles, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Total of Z and E isomers)
Isomeric Ratio (Z/E)	Specified on COA
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.