Description

1-Bromo-3-(Chloromethyl)-2-Fluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and fluorine substituents on a benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a multi-halogenated benzyl motif.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the halogenated aromatic core contributes to biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Bromo-3-(Chloromethyl)-2-Fluorobenzene
CAS No.	786652-60-6
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Fluoro-3-bromobenzyl chloride; 3-Bromo-2-fluorobenzyl chloride; 1-Bromo-3-(chloromethyl)-2-fluorobenzene; (3-Bromo-2-fluorophenyl)methyl chloride; 2-Fluoro-α-(chloromethyl)-3-bromobenzene; 3-Bromo-2-fluoro-benzylchloride; Benzene, 1-bromo-3-(chloromethyl)-2-fluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Chloromethyl)-2-Fluorobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of our global pharmaceutical and advanced materials customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.