Description

2,2-Difluoro-3-Methoxy-Propionic Acid is a specialized fluorinated organic acid building block. This compound is valued for its unique molecular structure, which combines a difluoro-substituted carbon and a methoxy ether group on a short propionic acid backbone, making it a versatile synthon for introducing fluorine atoms into target molecules. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the fluorine moiety can significantly alter biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro-methoxy moiety can enhance product efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and coatings with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands or metal-organic frameworks (MOFs) with specific catalytic or binding properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new fluorination methodologies and the synthesis of complex fluoroorganic molecules.
• Fine Chemical Synthesis: Utilized as a versatile intermediate for producing other high-value, fluorinated fine chemicals and specialty reagents.

Basic Information

Product Name	2,2-Difluoro-3-Methoxy-Propionic Acid
CAS No.	785712-17-6
Molecular Formula	C4H6F2O3
Molecular Weight	140.09 g/mol
Synonyms	2,2-Difluoro-3-methoxypropanoic Acid; 3-Methoxy-2,2-difluoropropionic Acid; α,α-Difluoro-β-methoxypropionic Acid; 2,2-Difluoro-3-methoxypropionic Acid; DFMPA; 785712-17-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-3-Methoxy-Propionic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases, oxidizing agents, and reactive metals. Ensure containers are kept upright to prevent leakage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.