Description

Dl-Erythro Ritalinic Acid CAS NO 783256-74-6 is a key chiral intermediate and the primary metabolite of the central nervous system stimulant methylphenidate. This compound is of significant interest in pharmaceutical research and development, particularly for analytical and metabolic studies. It serves as a critical reference standard and building block for chemists and researchers in the life sciences sector who require high-purity, well-characterized materials for method development, impurity profiling, and pharmacological investigations.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of methylphenidate and its metabolites in analytical methods.
• Metabolite Studies: Essential for in vitro and in vivo pharmacokinetic and pharmacodynamic research to understand the metabolism of methylphenidate.
• Impurity Profiling: Serves as a known impurity or degradation product standard in the quality control of active pharmaceutical ingredients (APIs) and finished drug products.
• Organic Synthesis Intermediate: Acts as a chiral synthon for the research-scale synthesis of novel compounds and analogs for biological screening.
• Forensic Analysis: Employed as a calibrant in forensic toxicology laboratories for the accurate detection of stimulant drugs and their metabolites in biological samples.
• Clinical Research: Utilized in the development and validation of bioanalytical assays for clinical trial sample analysis.

Basic Information

Product Name	Dl-Erythro Ritalinic Acid
CAS No.	783256-74-6
Molecular Formula	C14H19NO2
Molecular Weight	233.31 g/mol
Synonyms	α-Phenyl-2-piperidineacetic acid, (±)-threo-Methylphenidate acid, DL-threo-Ritalinic acid, Methylphenidate metabolite, Ritacid, DL-threo-α-Phenyl-2-piperidineacetic acid, (±)-threo-Ritalinic acid, 2-Piperidineacetic acid, α-phenyl-, (±)-threo-
EINECS	Contact for details

Quality Control

Our Dl-Erythro Ritalinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	Specified ratio of Dl-Erythro isomers
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.