Description

n-[(2S)-2-Pyrrolidinylmethyl]-Trifluoromethanesulfonamide is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, combining a pyrrolidine scaffold with a trifluoromethanesulfonamide (triflamide) group, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethanesulfonamide moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Acts as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research of advanced polymers and functional materials that require specific fluorine-containing motifs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and protein function.

Basic Information

Product Name	n-[(2S)-2-Pyrrolidinylmethyl]-Trifluoromethanesulfonamide
CAS No.	782495-18-5
Molecular Formula	C6H11F3N2O2S
Molecular Weight	232.23 g/mol
Synonyms	(S)-N-((Pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; (2S)-N-[(Pyrrolidin-2-yl)methyl]-1,1,1-trifluoromethanesulfonamide; 1,1,1-Trifluoro-N-[(2S)-2-pyrrolidinylmethyl]methanesulfonamide; (S)-Trifluoromethanesulfonic acid 2-pyrrolidinylmethylamide; (S)-2-(Trifluoromethanesulfonamidomethyl)pyrrolidine; Chiral Triflamide Pyrrolidine Derivative
EINECS	Contact for details

Quality Control

Our n-[(2S)-2-Pyrrolidinylmethyl]-Trifluoromethanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.