Description

Gd-Do3A-Butylamine CAS NO 782423-00-1 is a gadolinium-based macrocyclic complex, a key intermediate in the synthesis of advanced magnetic resonance imaging (MRI) contrast agents. Its stable, pre-formed chelate structure is critical for ensuring high thermodynamic and kinetic stability in the final diagnostic compound, directly addressing the pharmaceutical industry's need for safety and efficacy. This high-purity intermediate is essential for manufacturers developing next-generation contrast media for enhanced medical imaging.

Application

• Primary intermediate for synthesizing macrocyclic gadolinium-based MRI contrast agents (e.g., Gadobutrol analogs).
• Building block in research and development of novel diagnostic imaging pharmaceuticals.
• Precursor for targeted contrast agents in molecular imaging applications.
• Key material in the production of high-relaxivity agents for improved image quality.
• Used in the development of contrast media for magnetic resonance angiography (MRA).
• Critical component in GMP-grade manufacturing processes for injectable diagnostics.

Basic Information

Product Name	Gd-Do3A-Butylamine
CAS No.	782423-00-1
Molecular Formula	C14H26GdN4O6 (or similar based on exact isomer)
Molecular Weight	Contact for details
Synonyms	Gadolinium-1,4,7-tris(carboxymethyl)-10-(butylamino)-1,4,7,10-tetraazacyclododecane; Gadolinium-DO3A-butylamine; Gd-DO3A-BuNH2; 10-(Butylamino)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid gadolinium complex; Gadobutrol intermediate; Macrocyclic Gd(III) complex intermediate; DO3A-Butylamine-Gd(III)
EINECS	Contact for details

Quality Control

Our Gd-Do3A-Butylamine is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, residual solvent analysis, and elemental analysis to ensure identity, strength, and composition. We provide full traceability and Certificates of Analysis (COA) that detail all critical quality attributes, supporting our commitment to GMP-grade standards and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Gadolinium Content	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.