Description

(R,R)-7-Amino-3-(1-Methylpyrrolidinio)Methyl-3-Cephem-4-Carboxylate Hcl is a key advanced pharmaceutical intermediate (API intermediate) belonging to the cephalosporin class of β-lactam antibiotics. This high-purity compound is critical for the synthesis of next-generation cephalosporin antibiotics, offering a vital building block for pharmaceutical R&D and manufacturing. It is primarily utilized by pharmaceutical companies, research institutions, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of novel antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of advanced cephalosporin antibiotic active pharmaceutical ingredients (APIs).
• Antibiotic R&D: Serves as a key starting material for research and development of new antibacterial compounds with improved efficacy and spectrum.
• Process Chemistry: Used in scale-up and optimization of manufacturing routes for cephalosporin-based drugs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• GMP Manufacturing: Suitable for use in cGMP (Current Good Manufacturing Practice) compliant production processes for regulated markets.

Basic Information

Item	Detail
Product Name	(R,R)-7-Amino-3-(1-Methylpyrrolidinio)Methyl-3-Cephem-4-Carboxylate Hydrochloride
CAS No.	780810-20-0
Molecular Formula	C14H23ClN4O4S
Molecular Weight	378.88 g/mol
Synonyms	(6R,7R)-7-Amino-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride; 7-ACA derivative; Cephalosporin C-7 amine intermediate; (R,R)-7-ADCA pyrrolidinium derivative HCl; 7-Amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylic acid hydrochloride; 780810-20-0; Antibiotic intermediate
EINECS	Contact for details

Quality Control

Our (R,R)-7-Amino-3-(1-Methylpyrrolidinio)Methyl-3-Cephem-4-Carboxylate Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting compliance with ICH Q7 guidelines for API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.