Description

Boc-3-Amino-5-(Fmoc-Amino)-Benzoic Acid is a high-purity, dual-protected amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is essential for constructing complex peptide sequences where orthogonal protection of amine groups is required, enabling precise and sequential deprotection strategies. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs specializing in the development of novel therapeutic peptides, peptidomimetics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of modified benzoic acid derivatives into peptide chains, leveraging orthogonal Boc and Fmoc protecting groups.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new active pharmaceutical ingredients (APIs), particularly for creating peptide-based drugs and targeted therapies.
• Bioconjugation and Linker Chemistry: Serves as a versatile intermediate for attaching peptides to other molecules, surfaces, or carriers, such as in antibody-drug conjugates (ADCs) or diagnostic probes.
• Combinatorial Library Synthesis: Enables the generation of diverse compound libraries for high-throughput screening in the search for new bioactive molecules.
• Academic Research: A critical reagent for universities and research institutes studying peptide structure, function, and novel synthetic methodologies.
• Process Development & Scale-Up: Supports process chemistry teams in optimizing synthetic routes for the commercial-scale production of peptide therapeutics.

Basic Information

Product Name	Boc-3-Amino-5-(Fmoc-Amino)-Benzoic Acid
CAS No.	779335-06-7
Molecular Formula	C27H26N2O6
Molecular Weight	474.51 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]-5-[(9-fluorenylmethoxycarbonyl)amino]benzoic Acid; 3-(Boc-Amino)-5-(Fmoc-Amino)Benzoic Acid; 5-(Fmoc-Amino)-3-(Boc-Amino)Benzoic Acid; Boc-3,5-Diaminobenzoic Acid (Dual Protected); N3-Boc-N5-Fmoc-3,5-Diaminobenzoic Acid; Fmoc-5-Amino-Boc-3-Amino-Benzoic Acid; Dual-Protected 3,5-Diaminobenzoic Acid; Benzoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our Boc-3-Amino-5-(Fmoc-Amino)-Benzoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material that meets specific customer requirements for advanced pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.