Description

2-Hydroxy-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a phenolic hydroxyl group with a boronic acid moiety and a trifluoromethyl substituent, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in Suzuki-Miyaura cross-coupling reactions and as a key intermediate in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups, which are prevalent in modern drug discovery for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the boronic acid group enables efficient coupling to create diverse chemical libraries.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to form stable covalent bonds and introduce specific functional groups.
• Suzuki-Miyaura Cross-Coupling: Serves as a key organoboron reagent in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, a cornerstone methodology in complex molecule assembly.
• Medicinal Chemistry & Drug Discovery: Utilized in high-throughput screening and the synthesis of targeted compound libraries for probing biological pathways and identifying new therapeutic candidates.
• Chemical Biology Probe Development: Acts as a handle for bioconjugation and the creation of chemical probes to study protein function and enzyme activity.

Basic Information

Product Name	2-Hydroxy-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	779329-55-4
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	[2-Hydroxy-5-(trifluoromethyl)phenyl]boronic acid; 5-(Trifluoromethyl)-2-hydroxybenzeneboronic acid; 2-Hydroxy-5-trifluoromethylbenzeneboronic acid; (2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid; 2-Borono-4-(trifluoromethyl)phenol; 5-Trifluoromethylsalicylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.