Description

Boronic Acid, [1-[(1,1-Dimethylethyl)dimethylsilyl]-7-fluoro-1H-indol-3-yl]- (9Ci) is a sophisticated organoboron building block featuring a silyl-protected indole core. This compound is highly valued for its role as a key intermediate in modern synthetic chemistry, particularly in cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures. Its specific structure makes it essential for targeted synthesis programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex heterocyclic systems.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone of medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require fluoro-substituted indole motifs.
• Material Science & OLED Development: Employed in the synthesis of advanced organic electronic materials and fluorescent dyes due to its conjugated indole structure.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and bioconjugates to study biological processes and enzyme activity.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale production of fine chemicals.

Basic Information

Product Name	Boronic Acid, [1-[(1,1-Dimethylethyl)dimethylsilyl]-7-fluoro-1H-indol-3-yl]- (9Ci)
CAS No.	778647-36-2
Molecular Formula	C16H25BFNO2Si
Molecular Weight	321.28 g/mol
Synonyms	(7-Fluoro-1-[(tert-butyldimethylsilyl)-1H-indol-3-yl]boronic acid; 3-Borono-7-fluoro-1-(tert-butyldimethylsilyl)-1H-indole; [1-(tert-Butyldimethylsilyl)-7-fluoro-1H-indol-3-yl]boronic acid; 7-Fluoro-1-[(tert-butyldimethylsilyl)]-1H-indole-3-boronic acid; N-TBDMS-7-fluoro-3-indoleboronic acid; Boronic acid, B-[1-[(1,1-dimethylethyl)dimethylsilyl]-7-fluoro-1H-indol-3-yl]-; 778647-36-2
EINECS	Contact for details

Quality Control

Our Boronic Acid, [1-[(1,1-Dimethylethyl)dimethylsilyl]-7-fluoro-1H-indol-3-yl]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.