Description

Acetamide, n-(4,4-Dimethyl-3-Pyrrolidinyl)-2,2,2-Trifluoro-, (+)- (9Ci) is a high-purity, chiral trifluoroacetamide derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and other targeted therapies.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its unique pyrrolidine and trifluoroacetamide functionalities.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.

Basic Information

Product Name	Acetamide, n-(4,4-Dimethyl-3-Pyrrolidinyl)-2,2,2-Trifluoro-, (+)- (9Ci)
CAS No.	777827-09-5
Molecular Formula	C9H15F3N2O
Molecular Weight	224.23 g/mol
Synonyms	(+)-N-(4,4-Dimethyl-3-pyrrolidinyl)-2,2,2-trifluoroacetamide; (3R)-4,4-Dimethyl-3-(2,2,2-trifluoroacetamido)pyrrolidine; (R)-N-(4,4-Dimethylpyrrolidin-3-yl)-2,2,2-trifluoroacetamide; (R)-Trifluoroacetamide derivative of 4,4-dimethyl-3-aminopyrrolidine; 777827-09-5; Chiral Trifluoroacetamide Pyrrolidine Intermediate
EINECS	Contact for details

Quality Control

Our Acetamide, n-(4,4-Dimethyl-3-Pyrrolidinyl)-2,2,2-Trifluoro-, (+)- (9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity suitable for research and development. All materials are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including those for early-phase GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.