Description

(11Bs)-N,n-Bis[(S)-(+)-1-(2-Methoxyphenyl)Ethyl]Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is a sophisticated chiral phosphine-oxazoline (PHOX) ligand, a critical class of organocatalysts in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, which are essential for producing single-isomer pharmaceutical intermediates and fine chemicals. This high-purity ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in enantioselective C-C bond-forming reactions, such as Heck, Suzuki, and allylic alkylation.
• Key reagent for the asymmetric synthesis of chiral amines and amino acids, vital building blocks in drug discovery.
• Use in academic and industrial research to develop novel catalytic methodologies.
• Potential application in the synthesis of optically active natural products and complex molecules.
• Employed in the preparation of high-value specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	(11Bs)-N,n-Bis[(S)-(+)-1-(2-Methoxyphenyl)Ethyl]Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine
CAS No.	776316-48-4
Molecular Formula	C41H36NO3P
Molecular Weight	621.70 g/mol
Synonyms	(S,S)-MonoPhos; (S,S)-2-[(Diphenylphosphino)methyl]-4-(1-methylethyl)-4,5-dihydrooxazole; (S,S)-2-[(Diphenylphosphino)methyl]-4-isopropyl-4,5-dihydrooxazole; (S,S)-2-[(Diphenylphosphino)methyl]-4-isopropyl-2-oxazoline; PHOX Ligand; Chiral PHOX Ligand; (S,S)-iPr-PHOX; (S,S)-MonoPhos Oxazoline Ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be kept in the original packaging or an opaque secondary container until use. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.