Description

4-(T-Butyl)-1,2-Bis(Diphenylphosphino)-1'-(Di-I-Propylphosphino)Ferrocene, 98% Hiersophos-4 is a high-purity, chiral ferrocenyl diphosphine ligand designed for advanced asymmetric catalysis. This compound matters for its ability to impart exceptional enantioselectivity and catalytic activity in critical transition-metal-catalyzed reactions, enabling the synthesis of complex chiral molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and high-value intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical intermediates.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to construct chiral biaryl and other complex frameworks.
• Pharmaceutical Synthesis: Used in the research and process development of chiral active pharmaceutical ingredients (APIs) for enhanced efficacy and reduced side effects.
• Agrochemical Manufacturing: Applied in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring high optical purity.
• Catalyst Screening & Development: An essential tool in academic and industrial laboratories for discovering and optimizing new asymmetric catalytic processes.

Basic Information

Product Name	4-(T-Butyl)-1,2-Bis(Diphenylphosphino)-1'-(Di-I-Propylphosphino)Ferrocene, 98% Hiersophos-4
CAS No.	776315-37-8
Molecular Formula	C43H48FeP3
Molecular Weight	722.61 g/mol
Synonyms	Hiersophos-4; (Sp,Sp)-1-[(R)-1',2-Bis(diphenylphosphino)ferrocenyl]ethyl-diisopropylphosphine; (R,Sp,Sp)-1-[(R)-1',2-Bis(diphenylphosphino)ferrocenyl]ethyl-diisopropylphosphine; Josiphos-type ligand SL-J009-1; Ferrocenyl diphosphine ligand; Chiral Josiphos ligand; Asymmetric hydrogenation ligand; tBu-Josiphos derivative.
EINECS	Contact for details

Quality Control

Our 4-(T-Butyl)-1,2-Bis(Diphenylphosphino)-1'-(Di-I-Propylphosphino)Ferrocene is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.