Description

8-Azabicyclo[3.2.1]Oct-2-Ene-2-Carbonitrile,8-Methyl-,(1R,5S)-(9Ci) is a high-purity, stereochemically defined bicyclic nitrile building block of significant interest in advanced organic synthesis. Its unique bridged structure and functional groups make it a valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides due to its rigid bicyclic framework.
• Catalyst & Ligand Synthesis: Serves as a building block for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for introducing conformational constraint into bioactive molecules.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes to study biological pathways and enzyme mechanisms.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and exploring new chemical spaces.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Oct-2-Ene-2-Carbonitrile,8-Methyl-,(1R,5S)-(9Ci)
CAS No.	776294-65-6
Molecular Formula	C9H12N2
Molecular Weight	148.21 g/mol
Synonyms	(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carbonitrile; 8-Methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carbonitrile, (1R,5S)-; (1R,5S)-Trop-2-ene-2-carbonitrile, 8-Methyl-; 8-Methyl-8-azoniabicyclo[3.2.1]oct-2-ene-2-carbonitrile (endo isomer); Tropene nitrile derivative; Bicyclic nitrile intermediate; Chiral tropane derivative
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]Oct-2-Ene-2-Carbonitrile,8-Methyl-,(1R,5S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.