Description

1-Chloro-2-Fluoro-4-Methoxymethoxy-Benzene is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring chlorine, fluorine, and a protected methoxy group, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms can enhance compound efficacy and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for advanced electronic materials, where its aromatic structure and substituents help tune electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification of the benzene ring.
• Protecting Group Chemistry: The methoxymethoxy (MOM) group can act as a protecting group for phenols in multi-step synthetic sequences.
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorine substitution on aromatic systems in medicinal and materials chemistry.

Basic Information

Product Name	1-Chloro-2-Fluoro-4-Methoxymethoxy-Benzene
CAS No.	775334-11-7
Molecular Formula	C8H8ClFO2
Molecular Weight	190.60 g/mol
Synonyms	1-Chloro-2-fluoro-4-(methoxymethoxy)benzene; 4-Chloro-3-fluoroanisole MOM ether; 2-Fluoro-4-(methoxymethoxy)chlorobenzene; Benzene, 1-chloro-2-fluoro-4-(methoxymethoxy)-; 4-(Methoxymethoxy)-2-fluorochlorobenzene; MOM-protected 4-chloro-3-fluorophenol
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Fluoro-4-Methoxymethoxy-Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.