Description

Cyclobutanecarboxamide, 1-Amino-2-Methyl-, (1R,2S)- (9Ci) is a high-purity chiral intermediate featuring a cyclobutane ring system. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with defined three-dimensional configurations.
• Medicinal Chemistry Research: Serves as a core scaffold or a functionalized fragment in structure-activity relationship (SAR) studies and lead optimization programs.
• Agrochemical Development: Used in the research and synthesis of novel pesticides and herbicides where the cyclobutane moiety can impart unique biological activity.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, advanced materials, and ligands for catalysis.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and chemical biology.

Basic Information

Product Name	Cyclobutanecarboxamide, 1-Amino-2-Methyl-, (1R,2S)- (9Ci)
CAS No.	775281-65-7
Molecular Formula	C6H12N2O
Molecular Weight	128.17 g/mol
Synonyms	(1R,2S)-1-Amino-2-methylcyclobutanecarboxamide; (1R,2S)-2-Methyl-1-aminocyclobutanecarboxamide; (1R,2S)-1-Amino-2-methyl-1-cyclobutanecarboxamide; 1-Amino-2-methylcyclobutanecarboxamide, (1R,2S)-rel-; (1R,2S)-1-Amino-2-methylcyclobutanecarboxylic acid amide; Cyclobutanecarboxamide, 1-amino-2-methyl-, (1R,2S)-; 775281-65-7; (1R,2S)-2-Methylcyclobutane-1-carboxamide
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxamide, 1-Amino-2-Methyl-, (1R,2S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.