Description

Isoniazid-D4 is a stable isotope-labeled analog of the first-line antitubercular drug, Isoniazid, where four hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical analytical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies focused on drug development and bioanalytical method validation for tuberculosis treatments.

Application

• Internal Standard for LC-MS/MS: Primary use as a deuterated internal standard for the precise quantification of Isoniazid in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development: Serves as a critical reference material for developing and validating robust, sensitive, and selective HPLC-MS/MS assays.
• Forensic and Doping Analysis: Used in specialized testing laboratories for the definitive identification and quantification of Isoniazid.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assays for Isoniazid-based drug products.
• Metabolite Identification Studies: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometric analysis.

Basic Information

Product Name	Isoniazid-D4
CAS No.	774596-24-6
Molecular Formula	C6D4H3N3O
Molecular Weight	141.16 g/mol
Synonyms	Isonicotinoylhydrazine-D4; 4-Pyridinecarboxylic acid, hydrazide-D4; INH-D4; Isonicotinic acid hydrazide-D4; (Pyridine-4-carbonyl)hydrazine-D4; Deuteronated Isoniazid; [2H4]-Isoniazid; 4-Pyridinecarbohydrazide-D4
EINECS	Contact for details

Quality Control

Our Isoniazid-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0% (by NMR)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.