Description

Cetirizine-D8 is a deuterated analog of the widely used antihistamine cetirizine, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities. The high isotopic purity and chemical stability of this material are critical for ensuring the accuracy and reliability of mass spectrometry-based assays.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and quantification of cetirizine in drug substances and products.
• Bioanalytical Internal Standard: Used in LC-MS/MS and GC-MS methods for the accurate measurement of cetirizine concentrations in biological matrices such as plasma, serum, and urine.
• Metabolite Studies: Facilitates research into the metabolic pathways and pharmacokinetic profiles of cetirizine in preclinical and clinical studies.
• Doping Control Analysis: Employed in sports anti-doping laboratories as a critical standard for detecting cetirizine misuse.
• Forensic Toxicology: Acts as a key analytical standard in forensic investigations for the precise determination of cetirizine.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with ICH and FDA guidelines.

Basic Information

Product Name	Cetirizine-D8
CAS No.	774596-22-4
Molecular Formula	C21H17D8ClN2O3
Molecular Weight	394.93 g/mol
Synonyms	Cetirizine-d8; [2H8]-Cetirizine; 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid-d8; (±)-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid-d8; Zyrtec-d8; Deuterated Cetirizine
EINECS	Contact for details

Quality Control

Our Cetirizine-D8 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity suitable for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry standards for reference materials, and our quality system supports traceability and consistency for research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.