Description

tert-Butoxycarbonylamino-Phenyl-Acetic Acid is a high-purity, protected amino acid derivative, specifically a Boc-protected phenylglycine analog, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled synthesis of complex peptides and pharmaceutical intermediates, where the acid functionality and protected amine group allow for selective coupling and deprotection strategies. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in developing active pharmaceutical ingredients (APIs), peptide-based therapeutics, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis.
• Protease Inhibitor Development: Serves as a precursor in the research and production of enzyme inhibitors targeting proteases.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes and labeled biomolecules for research.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis services and the production of bespoke fine chemicals.

Basic Information

Product Name	tert-Butoxycarbonylamino-Phenyl-Acetic Acid
CAS No.	774225-57-9
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	Boc-Phenylglycine-OH; (tert-Butoxycarbonylamino)(phenyl)acetic acid; N-Boc-α-amino-phenylacetic acid; 2-[(tert-Butoxycarbonyl)amino]-2-phenylacetic acid; N-(tert-Butoxycarbonyl)-α-aminophenylacetic acid; Boc-Phe-Gly-OH (common abbreviation); N-Boc-phenylglycine; BOC-PHG-OH
EINECS	Contact for details

Quality Control

Our tert-Butoxycarbonylamino-Phenyl-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment to guarantee supply reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.