Description

1-Fluoro-4-Iodo-2-Methoxybenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring fluorine, iodine, and a methoxy group, makes it a critical intermediate for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new herbicides and pesticides, where the fluorine and iodine atoms contribute to biological activity and metabolic stability.
• Material Science: Serves as a building block for organic electronic materials, including charge-transport materials and liquid crystals for displays.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of molecular structures.
• Ligand Preparation: Useful for synthesizing sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Research: Employed in academic and industrial labs for method development and exploring new reaction pathways in organofluorine chemistry.

Basic Information

Product Name	1-Fluoro-4-Iodo-2-Methoxybenzene
CAS No.	773855-64-4
Molecular Formula	C7H6FIO
Molecular Weight	252.03 g/mol
Synonyms	4-Fluoro-2-iodoanisole; 2-Iodo-4-fluoroanisole; 2-Methoxy-5-fluoroiodobenzene; 5-Fluoro-2-iodoanisole; 1-Fluoro-2-methoxy-4-iodobenzene; 4-Fluoro-1-iodo-2-methoxybenzene; 2-Fluoro-5-iodoanisole
EINECS	Contact for details

Quality Control

Our 1-Fluoro-4-Iodo-2-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.