Description

4-(Pentafluorosulfur)Benzylamine is a specialized organofluorine building block characterized by a benzylamine core functionalized with a pentafluorosulfanyl (SF5) group. This unique structure imparts high lipophilicity, metabolic stability, and strong electron-withdrawing properties, making it a valuable intermediate for advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists working in agrochemical discovery, pharmaceutical development, and the synthesis of high-performance materials. The compound, identified by CAS number 771573-35-4, enables the introduction of the SF5 moiety, a "super-trifluoromethyl" group, into target molecules to fine-tune their physical and biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the SF5 group enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, where its strong dipole and stability contribute to improved performance in display and lighting technologies.
• Polymer & Functional Material Modifier: Incorporated into polymers and coatings to impart unique surface properties, chemical resistance, and durability.
• Positron Emission Tomography (PET) Tracer Development: Potential use in creating fluorine-18 labeled compounds for medical imaging due to the presence of multiple fluorine atoms.
• Catalyst & Ligand Design: Employed in the development of novel catalysts and ligands for asymmetric synthesis and other specialized chemical transformations.

Basic Information

Product Name	4-(Pentafluorosulfur)Benzylamine
CAS No.	771573-35-4
Molecular Formula	C7H6F5NS
Molecular Weight	231.19 g/mol
Synonyms	(4-(Pentafluoro-λ6-sulfanyl)phenyl)methanamine; 4-(SF5)Benzylamine; p-(Pentafluorosulfur)Benzylamine; 4-(Pentafluorosulfanyl)benzylamine; α-Amino-4-pentafluorosulfanyltoluene; Benzenemethanamine, 4-(pentafluoro-λ6-sulfanyl)-; 4-SF5-BnNH2
EINECS	Contact for details

Quality Control

Our 4-(Pentafluorosulfur)Benzylamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with global regulatory frameworks, and custom synthesis to specific purity grades (e.g., >97%, >98%, >99%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.