Description

Gadobutrol CAS NO 770691-21-9 is a macrocyclic, non-ionic gadolinium-based contrast agent. This compound is critically important for its paramagnetic properties, which enhance the visibility of internal body structures during magnetic resonance imaging (MRI). It is primarily required by pharmaceutical manufacturers and diagnostic imaging centers for the formulation of advanced MRI contrast media, enabling clearer and more precise diagnostic evaluations.

Application

• Primary active pharmaceutical ingredient (API) in magnetic resonance imaging (MRI) contrast agents.
• Used in the formulation of central nervous system (CNS) diagnostic imaging solutions to detect lesions, tumors, and vascular abnormalities.
• Essential for contrast-enhanced magnetic resonance angiography (CE-MRA) to visualize blood vessels.
• Key component in oncology imaging protocols for tumor characterization and staging.
• Employed in research and development of next-generation diagnostic imaging compounds.
• Used in quality control and analytical reference standards for pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	Gadobutrol
CAS No.	770691-21-9
Molecular Formula	C18H31GdN4O9
Molecular Weight	604.72 g/mol
Synonyms	Gadobutrolum; Gadovist; Gadavist; 10-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetatogadolinium; (4R)-4-[(1R)-1-Hydroxyethyl]-10-[2,3-dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetatogadolinium; BAY86-4875; Gd-BT-DO3A; Gadolinium chelate of 10-(2,3-dihydroxy-1-hydroxymethylpropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
EINECS	Contact for details

Quality Control

Our Gadobutrol is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity pharmaceutical standards, including specifications for assay, impurity profiles, and residual solvents. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing compliance with relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature. Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term stability, storage under an inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
pH (in solution)	6.5 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.