Description

2,4-Difluoro-3-(trifluoromethyl)phenylboronic acid is a high-value, multi-fluorinated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce a highly fluorinated aromatic moiety to enhance metabolic stability, lipophilicity, and bioavailability in active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the difluoro- and trifluoromethyl groups contribute to improved efficacy and environmental profile.
• Material Science: Employed in the development of specialty polymers, liquid crystals, and organic light-emitting diodes (OLEDs) to fine-tune electronic properties and stability.
• Chemical Research & Development: Serves as a versatile reagent in academic and industrial R&D for exploring new synthetic pathways and creating novel fluorinated compound libraries.
• Suzuki-Miyaura Cross-Coupling: Functions as a highly effective coupling partner with various aryl halides to form biaryl structures, a fundamental transformation in medicinal chemistry.

Basic Information

Product Name	2,4-Difluoro-3-(trifluoromethyl)phenylboronic Acid
CAS No.	769937-40-8
Molecular Formula	C7H4BF5O2
Molecular Weight	225.91 g/mol
Synonyms	[2,4-Difluoro-3-(trifluoromethyl)phenyl]boronic acid; 2,4-Difluoro-3-(trifluoromethyl)benzeneboronic acid; (2,4-Difluoro-3-(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[2,4-difluoro-3-(trifluoromethyl)phenyl]-; 3-Trifluoromethyl-2,4-difluorophenylboronic acid; 769937-40-8; B-(2,4-Difluoro-3-(trifluoromethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-(trifluoromethyl)phenylboronic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.