Description

2-Propynamide, n-[[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl]Methyl]- (9Ci) is a high-purity, stereochemically defined pyrrolidine derivative that serves as a critical chiral building block and synthetic intermediate. Its value lies in its complex, multifunctional structure, which provides multiple points for selective chemical modification, enabling the synthesis of sophisticated target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require advanced intermediates for drug discovery, process development, and the production of active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in antiviral, anticancer, and neurological drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probe Development: Serves as a scaffold for designing molecular probes to study enzyme mechanisms and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Its structure can be modified to create novel chiral ligands for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for synthetic organic chemistry research in academic institutions and CROs (Contract Research Organizations).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules under Good Manufacturing Practice (GMP) conditions where applicable.

Basic Information

Product Name	2-Propynamide, n-[[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl]Methyl]- (9Ci)
CAS No.	765308-97-2
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	N-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]methylprop-2-ynamide; (2R,3R,4R,5R)-2-[(Propiolamidomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol; Propiolamide derivative of (2R,3R,4R,5R)-2-(Aminomethyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol; Chiral Pyrrolidine Propiolamide; 765308-97-2 (CAS Index Name); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Propynamide, n-[[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl]Methyl]- (9Ci) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.