Description

3-(Nicotinoyl-2,4,5,6-D4)-2-Pyrrolidinone CAS NO 764661-25-8 is a deuterium-labeled isotopologue of a key intermediate in the synthesis of nootropic and neuroprotective agents. This high-purity compound is essential for pharmaceutical research and development, particularly in the creation of deuterated drug candidates where metabolic stability and pharmacokinetic profiling are critical. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for applications in drug discovery, metabolic studies, and as an internal standard for analytical quantification.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block for the development of deuterium-enriched versions of nootropic drugs, aiming to improve metabolic stability and patent life.
• Metabolic Pathway Tracing: Used in pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies to track the fate of molecules in biological systems using mass spectrometry.
• Internal Standard for Quantitative Analysis: Employed in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) as a stable, isotopically labeled internal standard to ensure accurate quantification of the non-deuterated parent compound in complex matrices.
• Neurological Research: Applied in preclinical research for investigating mechanisms related to cognitive enhancement and neuroprotection.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of deuterated pharmaceuticals.
• Reference Standard: Provides a certified material for quality control and regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	3-(Nicotinoyl-2,4,5,6-D4)-2-Pyrrolidinone
CAS No.	764661-25-8
Molecular Formula	C10H8D4N2O2
Molecular Weight	196.23 g/mol
Synonyms	2-Pyrrolidinone, 3-(2,4,5,6-tetradeuterio-3-pyridinecarbonyl)-; 3-(Nicotinoyl-d4)-2-pyrrolidinone; Deuterated Pramiracetam Intermediate; 3-(2,4,5,6-Tetradeuteronicotinoyl)-2-pyrrolidinone; Nootropic Deuterated Intermediate; 1-(2-Oxopyrrolidin-3-yl)-2,4,5,6-tetradeuteriopyridin-1-ium-3-carboxylate
EINECS	Contact for details

Quality Control

Our 3-(Nicotinoyl-2,4,5,6-D4)-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, and ²H) for structural and isotopic purity confirmation, HPLC for chemical purity, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity (typically >97%), and residual solvent levels, supporting research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.