Description

Ethyl 2-Amino-3,3,3-trifluoropropanoate is a versatile fluorinated amino acid ester building block. This compound is valued for its unique trifluoromethyl group, which imparts enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its role as a key intermediate enables the efficient construction of complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity.
• Peptidomimetics & Bioisosteres: Serves as a non-natural amino acid analog for creating peptide mimics with improved stability and pharmacokinetic profiles.
• Material Science Research: Employed in the development of specialty polymers and advanced materials that benefit from fluorine's unique properties.
• Chemical Biology Probes: Utilized as a precursor for labeling reagents and molecular probes used in drug discovery and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the incorporation of a trifluoromethylated β-amino acid scaffold.

Basic Information

Product Name	Ethyl 2-Amino-3,3,3-trifluoropropanoate
CAS No.	764629-04-1
Molecular Formula	C5H8F3NO2
Molecular Weight	171.12 g/mol
Synonyms	2-Amino-3,3,3-trifluoropropanoic acid ethyl ester; Ethyl 2-amino-3,3,3-trifluoropropionate; 3,3,3-Trifluoroalanine ethyl ester; Ethyl 3,3,3-trifluoroalaninate; Alanine, 3,3,3-trifluoro-, ethyl ester; Ethyl β-amino-β-trifluoromethylpropionate; TF-Ala-OEt; 764629-04-1
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-3,3,3-trifluoropropanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.