Description

Carbamic Acid, [(1S)-1-(Hydroxymethyl)-3-Butynyl]-, 1,1-Dimethylethyl Ester is a high-purity chiral building block featuring both a terminal alkyne and a protected carbamate group. This compound is critical for advanced pharmaceutical synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Peptide Mimetics & Conjugation: The terminal alkyne group enables efficient click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), for bioconjugation and labeling.
• Agrochemical Research: Serves as a building block for synthesizing advanced crop protection agents with specific modes of action.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and biological pathways due to its reactive handles.
• Material Science: Potential monomer or cross-linker in the development of specialty polymers with tailored properties.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes requiring this precise molecular architecture.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-(Hydroxymethyl)-3-Butynyl]-, 1,1-Dimethylethyl Ester
CAS No.	763122-73-2
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	N-Boc-3-butyn-1-ol, (S)-; (S)-tert-Butyl (4-hydroxybut-2-yn-1-yl)carbamate; (S)-N-Boc-3-butyn-1-amine; (S)-tert-Butyl (1-hydroxy-3-butyn-2-yl)carbamate; (1S)-1-(Hydroxymethyl)-3-butynyl carbamic acid tert-butyl ester; tert-Butyl N-[(1S)-1-(hydroxymethyl)-3-butynyl]carbamate; Boc-(S)-3-butyn-1-ol; 763122-73-2
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-1-(Hydroxymethyl)-3-Butynyl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques (HPLC, GC, NMR) to ensure high chemical and chiral purity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.