Description

(R)-n-β-Fmoc-n-γ-Boc-3,4-Diaminobutyric Acid is a high-purity, orthogonally protected diaminobutyric acid derivative essential for advanced peptide synthesis. This compound matters because it provides critical chiral building blocks for constructing complex peptides and peptidomimetics with precise stereochemistry. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic agents, including enzyme inhibitors and receptor ligands, where the (R)-configuration and protected amine functionalities are crucial.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral intermediate for the controlled incorporation of 3,4-diaminobutyric acid residues into peptide chains.
• Pharmaceutical Research & Development: Building block for the synthesis of peptide-based drug candidates, protease inhibitors, and targeted biologics.
• Peptidomimetic Design: Used to create stable, bioavailable analogs of natural peptides by modifying the peptide backbone.
• Combinatorial Chemistry Libraries: Serves as a diversified monomer for generating libraries of compounds for high-throughput screening.
• Bioconjugation: The orthogonal Fmoc and Boc protecting groups allow for selective deprotection, enabling site-specific conjugation with other molecules.
• Academic & Industrial Research: Fundamental reagent for studies in medicinal chemistry, chemical biology, and structural biology.

Basic Information

Product Name	(R)-n-β-Fmoc-n-γ-Boc-3,4-Diaminobutyric Acid
CAS No.	763102-80-3
Molecular Formula	C25H30N2O6
Molecular Weight	454.52 g/mol
Synonyms	(R)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-4-[(tert-butoxycarbonyl)amino]butanoic Acid; Fmoc-Dab(Boc)-OH (R-isomer); (R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[(tert-butoxycarbonyl)amino]propanoic Acid (alternative numbering); (R)-Nβ-Fmoc-Nγ-Boc-2,4-diaminobutyric Acid; (R)-Nα-Fmoc-Nγ-Boc-diaminobutyric Acid; Fmoc-Dab(Boc)-OH (configuration R); (R)-3-Fmoc-amino-4-Boc-aminobutyric Acid; Boc-Dab(Fmoc)-OH (R)
EINECS	Contact for details

Quality Control

Our (R)-n-β-Fmoc-n-γ-Boc-3,4-Diaminobutyric Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and production. Each lot undergoes rigorous analytical testing, including chiral purity verification, to meet the high standards required for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.