Description

Oxazole, 2-[[2-(Diphenylphosphino)Phenyl]Methyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4S)- is a sophisticated chiral organophosphorus-oxazole hybrid ligand. This compound matters for its ability to impart high enantioselectivity and catalytic activity in asymmetric synthesis, a critical requirement for producing optically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their catalytic processes.

Application

• As a chiral ligand in asymmetric hydrogenation and other transition metal-catalyzed reactions.
• Key intermediate in the research and development of novel active pharmaceutical ingredients (APIs).
• Catalyst component for the synthesis of enantiomerically pure agrochemicals and flavors/fragrances.
• Use in academic and industrial research for developing new catalytic methodologies.
• Potential application in materials science for creating chiral molecular frameworks.

Basic Information

Item	Details
Product Name	Oxazole, 2-[[2-(Diphenylphosphino)Phenyl]Methyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4S)-
CAS No.	761402-25-9
Molecular Formula	C31H30NOP
Molecular Weight	463.55 g/mol
Synonyms	(4S)-2-[[2-(Diphenylphosphino)Phenyl]Methyl]-4-(1-Methylethyl)-4,5-Dihydrooxazole; (S)-2-((2-(Diphenylphosphino)benzyl)-4-isopropyl-4,5-dihydrooxazole; (S)-4-Isopropyl-2-((2-(diphenylphosphino)benzyl)-4,5-dihydrooxazole; Chiral PHOX ligand derivative; P,N-Ligand; Josiphos-type ligand analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC or NMR), chiral purity, and residual solvent content are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.