Description

2-Pyridinecarbonitrile, 3-Bromo-5-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block. This compound matters for its unique molecular architecture, combining a bromo-substituent for cross-coupling reactions and a trifluoromethyl group to impart desirable metabolic stability and lipophilicity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the trifluoromethyl group enhances biological activity.
• Material Science Precursor: Serves as a starting material for synthesizing functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom enables efficient Suzuki, Stille, and Buchwald-Hartwig amination reactions for carbon-carbon and carbon-nitrogen bond formation.
• Fluorine Chemistry Building Block: Essential for introducing the trifluoromethyl moiety into target molecules to fine-tune their physicochemical properties.

Basic Information

Product Name	2-Pyridinecarbonitrile, 3-Bromo-5-(Trifluoromethyl)-
CAS No.	760207-85-0
Molecular Formula	C7H2BrF3N2
Molecular Weight	250.99 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)picolinonitrile; 3-Bromo-5-(trifluoromethyl)-2-cyanopyridine; 2-Cyano-3-bromo-5-(trifluoromethyl)pyridine; 3-Bromo-5-trifluoromethylpyridine-2-carbonitrile; Picolinonitrile, 3-bromo-5-(trifluoromethyl)-; 3-Bromo-5-(trifluoromethyl)-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for advanced research and scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports cGMP and ISO standards for traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.