Description

[2-Fluoro-5-(Prop-2-Enamido)Phenyl]Boronic Acid is a specialized boronic acid derivative featuring a reactive acrylamide group, making it a valuable bifunctional building block for advanced organic synthesis. This compound is engineered to serve as a key intermediate in the construction of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted therapies and kinase inhibitors.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent for creating advanced polymers, coatings, and functional surfaces.
• Bioconjugation & Probe Development: The acrylamide moiety enables Michael addition reactions for labeling proteins, peptides, and other biomolecules.
• Chemical Biology: Employed in the design and synthesis of molecular probes and inhibitors for studying biological pathways.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	[2-Fluoro-5-(Prop-2-Enamido)Phenyl]Boronic Acid
CAS No.	758697-67-5
Molecular Formula	C9H9BFNO3
Molecular Weight	209.98 g/mol
Synonyms	2-Fluoro-5-acrylamidophenylboronic acid; 5-Acrylamido-2-fluorophenylboronic acid; (2-Fluoro-5-acrylamidophenyl)boronic acid; 2-Fluoro-5-[(1-oxoprop-2-en-1-yl)amino]benzeneboronic acid; 758697-67-5; B-[2-Fluoro-5-(prop-2-enamido)phenyl]boronic acid; Acrylamido-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our [2-Fluoro-5-(Prop-2-Enamido)Phenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards for pharmaceutical-grade production, ensuring compliance with global regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.