Description

Di(n-Desethyl) Amiodarone Hydrochloride is a key pharmaceutical intermediate and reference standard, primarily used in the research, development, and quality control of cardiovascular drugs. This compound is critical for ensuring the purity, safety, and efficacy of related pharmaceutical products. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on antiarrhythmic agents and metabolite studies.

Application

• Primary reference standard for the analytical quantification of Amiodarone and its metabolites in pharmaceutical formulations and biological samples.
• Critical intermediate in the research and development of novel antiarrhythmic drugs and their derivatives.
• Used in pharmacokinetic and metabolic pathway studies to understand drug behavior and clearance.
• Essential component in the quality control (QC) and quality assurance (QA) processes for pharmaceutical manufacturing, ensuring batch-to-batch consistency.
• Impurity standard for method development and validation in high-performance liquid chromatography (HPLC) and other analytical techniques.
• Starting material or building block for the synthesis of specialized chemical probes used in cardiovascular research.

Basic Information

Product Name	Di(n-Desethyl) Amiodarone Hydrochloride
CAS No.	757220-04-5
Molecular Formula	C23H25I2NO3 • HCl
Molecular Weight	694.73 g/mol
Synonyms	2-Butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride; Desethylamiodarone Hydrochloride; N-Desethylamiodarone Hydrochloride; Amiodarone Metabolite II Hydrochloride; DEA Hydrochloride; NSC 339539 Hydrochloride; L 3428 Hydrochloride
EINECS	Contact for details

Quality Control

Our Di(n-Desethyl) Amiodarone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.