Description

Fmoc-Nh-Peg8-Ch2Ch2Cooh is a specialized, high-purity polyethylene glycol (PEG)-based linker molecule featuring a carboxylic acid terminus and an Fmoc-protected amine. This compound is engineered to provide a hydrophilic spacer arm for the conjugation of biomolecules, peptides, and active pharmaceutical ingredients (APIs), enhancing solubility and bioavailability. It is an essential building block for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require precise and reliable linker chemistry for drug delivery systems, diagnostic probes, and bioconjugate development.

Application

• Bioconjugation and ADC Development: Serves as a critical hydrophilic linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) manufacturing, improving pharmacokinetics.
• Peptide Synthesis and Modification: Used in solid-phase peptide synthesis (SPPS) to introduce a solubilizing PEG spacer and a protected amine for further functionalization.
• Drug Delivery System Fabrication: Incorporated into polymer-drug conjugates and nanoparticle formulations to enhance water solubility and control the release profile of therapeutic agents.
• Diagnostic Reagent Preparation: Acts as a spacer for attaching fluorescent dyes, targeting ligands, or other reporter molecules to proteins and oligonucleotides.
• Surface Functionalization: Utilized to modify surfaces (e.g., biosensors, chips) with a carboxylic acid group for subsequent covalent immobilization of biomolecules.
• Cross-linking and Biopolymer Engineering: Employed as a heterobifunctional cross-linker to bridge amine-containing and carboxyl-reactive molecules in hydrogel and biomaterial synthesis.

Basic Information

Product Name	Fmoc-Nh-Peg8-Ch2Ch2Cooh
CAS No.	756526-02-0
Molecular Formula	C46H71NO19
Molecular Weight	942.06 g/mol
Synonyms	Fmoc-NH-PEG8-CH2CH2COOH; Fmoc-8-amino-3,6-dioxaoctanoic acid-PEG8-acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid; 27-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,6,9,12,15,18,21,24-octaoxaheptacosanoic Acid; Fmoc-N-amido-PEG8-acid; Fmoc-PEG8-CH2CH2-COOH; Fmoc-AEEA-PEG8-acid; Fmoc-NH-(CH2CH2O)8-CH2CH2COOH
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-Peg8-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.