Description

Mal-Peg2-Cooh CAS NO 756525-98-1 is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a carboxylic acid at the other, separated by a short PEG spacer. This molecular architecture is critical for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules like antibodies, peptides, or proteins to various payloads, surfaces, or other functional groups. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science, where controlled conjugation is paramount.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• PEGylation of Peptides and Proteins: Introduction of a carboxylic acid handle for further modification while improving solubility and stability.
• Diagnostic Probe and Biosensor Fabrication: Immobilization of capture antibodies or proteins onto activated surfaces (e.g., NHS-ester, EDC chemistry) for ELISA, lateral flow assays, or microarray chips.
• Nanoparticle Functionalization: Conjugation of targeting ligands (via maleimide-thiol chemistry) to nanoparticles for drug delivery or imaging applications.
• Crosslinking and Bioconjugation Kits: A key component in reagent kits designed for labeling, crosslinking, or immobilization workflows.
• Surface Plasmon Resonance (SPR) Chip Coating: Creating defined ligand surfaces on sensor chips for biomolecular interaction analysis.

Basic Information

Product Name	Mal-Peg2-Cooh CAS NO 756525-98-1
CAS No.	756525-98-1
Molecular Formula	C15H23NO8
Molecular Weight	345.35 g/mol
Synonyms	Maleimide-PEG2-acid; 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid; 1-(8-Carboxy-3,6-dioxaoctyl)-1H-pyrrole-2,5-dione; Mal-PEG2-COOH; Maleimide-PEG2-Propionic Acid; Maleimido-PEG2-acid; CAS 756525-98-1; mPEG2-Mal
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Assay	95 - 105%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.