Description

Mpeg11-Nhs CAS NO 756525-94-7 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an N-hydroxysuccinimide (NHS) ester at one terminus and a methoxy group at the other. This compound is engineered to facilitate the stable, covalent conjugation of biomolecules, such as proteins and peptides, to other surfaces or molecules under mild aqueous conditions. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and diagnostic assay development, where precise and reliable cross-linking is paramount.

Application

• Bioconjugation Reagent: For covalently linking amines on proteins, antibodies, or peptides to other functional groups or surfaces.
• PEGylation Chemistry: Used in the synthesis of PEGylated therapeutics to improve pharmacokinetics, solubility, and stability of drugs.
• Diagnostic Kit Development: Employed in the preparation of enzyme-labeled antibodies or antigens for ELISA and other immunoassays.
• Surface Functionalization: Modifying nanoparticles, biosensors, or microarray slides with bioactive molecules for targeted applications.
• Cross-linking Agent: Creating stable bridges between different biomolecules in structural biology and materials science.
• Drug Delivery System Fabrication: Building functional components of micelles, liposomes, or polymer-drug conjugates.

Basic Information

Product Name	Mpeg11-Nhs
CAS No.	756525-94-7
Molecular Formula	C26H47NO14
Molecular Weight	597.65 g/mol
Synonyms	mPEG11-NHS Ester; Methoxy PEG11 NHS Ester; α-Methoxy-ω-succinimidyl undeca(ethylene glycol); Succinimidyl ester of monomethoxy undecaethylene glycol; NHS-PEG11-OMe; O-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-Methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethylcarboxylate) N-hydroxysuccinimide; PEG11 spacer NHS ester
EINECS	Contact for details

Quality Control

Our Mpeg11-Nhs is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, functional group assay, and critical impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Assay (NHS Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.