Description

n-Methyl-N’-Nitrosopiperazine-D4 is a stable isotope-labeled analog of a nitrosamine compound, specifically deuterated at four positions. This high-purity chemical standard is critical for ensuring analytical accuracy and traceability in sensitive detection methods. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, environmental, and food safety sectors for use as an internal standard in mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of n-Methyl-N-nitrosopiperazine and related nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products.
• Pharmaceutical Impurity Testing: Used in method development and validation to comply with stringent regulatory guidelines (e.g., FDA, EMA) for nitrosamine risk assessment.
• Metabolic and Pharmacokinetic Studies: Serves as a tracer in advanced ADME (Absorption, Distribution, Metabolism, and Excretion) research utilizing deuterium labeling.
• Environmental and Food Safety Analysis: Enables accurate monitoring and detection of nitrosamine contaminants in water, food, and consumer products.
• Reference Material for Calibration: Provides a certified reference point for calibrating analytical instruments, ensuring data reliability and reproducibility.
• Research on Nitrosamine Formation and Chemistry: Supports fundamental and applied research into the mechanisms of nitrosamine generation and degradation.

Basic Information

Product Name	n-Methyl-N’-Nitrosopiperazine-D4
CAS No.	756524-88-6
Molecular Formula	C5H6D4N4O
Molecular Weight	130.17 g/mol
Synonyms	1-Methyl-4-nitrosopiperazine-d4; N-Methyl-N-nitrosopiperazine-d4; MNZP-d4; N-Nitroso-N-methylpiperazine-d4; 1-Methyl-4-nitroso-piperazine-d4; N-Nitrosomethylpiperazine-d4; Deuterated N-Methyl-N-nitrosopiperazine; [2H4]-N-Methyl-N-nitrosopiperazine
EINECS	Contact for details

Quality Control

Every batch of n-Methyl-N’-Nitrosopiperazine-D4 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity, isotopic enrichment, and solvent content to support your regulatory submissions and quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. Due to its highly volatile nature, ensure containers are securely sealed and stored in a well-ventilated area. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Yellow to orange liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by GC or HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.