Description

2,2,2-Trifluoro-n-[(3-Methyl-3-Azetidinyl)Methyl]-Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroacetamide moiety linked to a substituted azetidine ring. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including potential candidates in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its trifluoromethyl and azetidine functional groups.
• Preclinical Drug Development: Serves as a crucial starting material for synthesizing candidate compounds for pharmacological screening and testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for exploring novel heterocyclic chemistry and fluorine chemistry applications.

Basic Information

Product Name	2,2,2-Trifluoro-n-[(3-Methyl-3-Azetidinyl)Methyl]-Acetamide
CAS No.	756444-40-3
Molecular Formula	C7H11F3N2O
Molecular Weight	196.17 g/mol
Synonyms	N-[(3-Methylazetidin-3-yl)methyl]-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-[(3-methylazetidin-3-yl)methyl]acetamide; 3-[(2,2,2-Trifluoroacetamido)methyl]-3-methylazetidine; 3-Methyl-3-azetidinemethanol, trifluoroacetamide; (3-Methyl-3-azetidinyl)methyl trifluoroacetamide; Trifluoroacetamide, N-[(3-methyl-3-azetidinyl)methyl]-; 756444-40-3
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-[(3-Methyl-3-Azetidinyl)Methyl]-Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.