Description

3-Fluoro-4-Methoxyphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its enhanced stability and handling properties compared to the free boronic acid, making it an ideal reagent for demanding cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for constructing complex molecular architectures. Its specific substitution pattern offers precise control in the synthesis of fluorinated and methoxylated target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing fluorinated aryl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the 3-fluoro-4-methoxy phenyl group imparts specific biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors, where precise molecular structure is crucial for performance.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A reliable, high-quality starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Fluoro-4-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	754226-34-1
Molecular Formula	C₁₃H₁₈BFO₃
Molecular Weight	252.09 g/mol
Synonyms	3-Fluoro-4-methoxyphenylboronic acid pinacol ester; 2-(3-Fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Fluoro-4-methoxyphenyl)boronic acid pinacol ester; 3-Fluoro-4-methoxybenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(3-fluoro-4-methoxyphenyl)-1,3,2-dioxaborolane; Pinacol (3-Fluoro-4-methoxyphenyl)boronate; Boronic acid, B-(3-fluoro-4-methoxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Methoxyphenylboronic Acid, Pinacol Ester is produced and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98.0-99.5%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.