Description

cis-4-Aminocyclohexane-1-Carboxamide is a high-purity, functionalized cyclohexane derivative featuring both an amine and a carboxamide group in a specific stereochemical configuration. This compound serves as a versatile and valuable chiral building block in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate a rigid, substituted cyclohexane scaffold into their target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the cis-aminocyclohexane structure can contribute to biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Peptidomimetics and Bioisosteres: The carboxamide and amine functionalities make it suitable for constructing peptide analogs and bioisosteric replacements in medicinal chemistry programs.
• Material Science Research: Potential monomer or additive for creating specialized polymers with unique thermal or mechanical properties derived from the cyclohexane backbone.
• Chemical Biology Probes: Used to synthesize molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	cis-4-Aminocyclohexane-1-Carboxamide
CAS No.	754182-14-4
Molecular Formula	C7H14N2O
Molecular Weight	142.20 g/mol
Synonyms	cis-4-Aminocyclohexanecarboxamide; (1r,4r)-4-Aminocyclohexane-1-carboxamide; 4-Amino-cyclohexanecarboxylic acid amide (cis); 4-Aminocyclohexanecarboxamide (cis); cis-4-Aminocyclohexanecarboxylic acid amide; Cyclohexanecarboxamide, 4-amino-, cis-; 4-Aminocyclohexanecarboxamide; 754182-14-4
EINECS	Contact for details

Quality Control

Our cis-4-Aminocyclohexane-1-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.