Description

2,2,2-Trifluoro-n-(3-Methyl-3-Azetidinyl)-Acetamide is a high-purity trifluoromethylated acetamide derivative featuring a substituted azetidine ring, a structure of significant interest in modern synthetic chemistry. This compound matters as a sophisticated pharmaceutical intermediate and key building block for the development of novel active ingredients, particularly in medicinal chemistry programs. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate fluorine and constrained ring systems into new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to improve potency, metabolic stability, and bioavailability.
• Agrochemical Development: Serves as a precursor for creating new generation pesticides and herbicides with enhanced efficacy and environmental profile.
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethylacetamide moiety into complex molecules, leveraging the unique properties of fluorine.
• Constrained Ring System Synthesis: Utilized in the construction and functionalization of azetidine rings, which are valuable scaffolds in drug design.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of target molecules under cGMP conditions where required.

Basic Information

Product Name	2,2,2-Trifluoro-n-(3-Methyl-3-Azetidinyl)-Acetamide
CAS No.	754151-01-4
Molecular Formula	C7H11F3N2O
Molecular Weight	196.17 g/mol
Synonyms	N-(3-Methylazetidin-3-yl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(3-methyl-3-azetidinyl)acetamide; 3-Methyl-3-azetidinamine, N-(trifluoroacetyl)-; 2,2,2-Trifluoroacetamide, N-(3-methyl-3-azetidinyl)-; Trifluoro-N-(3-methylazetidin-3-yl)acetamide; 3-(Trifluoroacetamido)-3-methylazetidine; 754151-01-4 (CAS); TFA-3-Methylazetidine Amide
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(3-Methyl-3-Azetidinyl)-Acetamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development projects requiring material produced under cGMP guidelines for advanced clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.