Description

Fmoc-6-Bromo-Dl-Tryptophan CAS NO 753504-16-4 is a protected amino acid derivative, specifically a brominated tryptophan analog with an N-terminal Fmoc (9-fluorenylmethoxycarbonyl) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of a modified tryptophan residue into complex peptide sequences. It is primarily utilized by pharmaceutical researchers, peptide manufacturers, and biotechnology companies for the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated synthesis of custom peptides containing brominated tryptophan.
• Pharmaceutical Research: For the development of peptide-based drug candidates where the bromine atom serves as a handle for further chemical modification (e.g., cross-coupling reactions).
• Bioconjugation & Probe Development: Used to create labeled peptides for imaging, diagnostic assays, or studying protein-protein interactions.
• Chemical Biology Studies: Incorporation into peptides to investigate the role of halogenated amino acids in protein structure, function, and stability.
• Academic Research: A reagent for synthetic organic chemistry and peptide science laboratories exploring novel amino acid derivatives.
• Production of Non-Natural Peptides: Enables the synthesis of peptides with enhanced properties such as increased metabolic stability or altered binding affinity.

Basic Information

Product Name	Fmoc-6-Bromo-Dl-Tryptophan
CAS No.	753504-16-4
Molecular Formula	C₂₆H₂₁BrN₂O₄
Molecular Weight	505.36 g/mol
Synonyms	Fmoc-6-Bromo-DL-Trp; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-bromo-DL-tryptophan; 6-Bromo-DL-tryptophan N-Fmoc derivative; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(6-bromo-1H-indol-3-yl)propanoic acid; Fmoc-6-Br-DL-Trp-OH; N-Fmoc-6-bromo-DL-tryptophan; 6-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-DL-tryptophan
EINECS	Contact for details

Quality Control

Our Fmoc-6-Bromo-Dl-Tryptophan is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.