Description

Ronacaleret is a potent and selective calcium-sensing receptor (CaSR) antagonist with significant research and therapeutic potential. This compound is primarily utilized in the investigation of bone metabolism disorders and as a key intermediate in advanced pharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on metabolic bone diseases, such as osteoporosis and hyperparathyroidism.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics targeting the calcium-sensing receptor.
• Metabolic Bone Disease Studies: Used in preclinical and clinical research to investigate pathways and potential treatments for conditions like osteoporosis, chronic kidney disease-mineral and bone disorder (CKD-MBD), and hyperparathyroidism.
• Biochemical Assay Development: Employed as a tool compound in high-throughput screening (HTS) and in vitro assays to study CaSR function and signal transduction mechanisms.
• Academic Research: A valuable reagent for universities and research institutions exploring calcium homeostasis, bone biology, and endocrine regulation.
• Process Chemistry & Scale-up: Acts as a key building block for process chemists during the optimization and commercial-scale synthesis of related drug candidates.

Basic Information

Product Name	Ronacaleret
CAS No.	753449-67-1
Molecular Formula	C₂₀H₂₀F₃N₃O₃
Molecular Weight	407.39 g/mol
Synonyms	N-((1R)-1-{[(3-Cyanophenyl)sulfonyl]amino}ethyl)-4-fluoro-β,β-bis(3-fluorophenyl)benzenepropanamide; SB-751689; MK-5442; Calcilytic SB-751689; Ronacaleret Hydrochloride (salt form); Calcium-sensing receptor antagonist SB-751689; N-[(1R)-1-[[(3-Cyanophenyl)sulfonyl]amino]ethyl]-4-fluoro-β,β-bis(3-fluorophenyl)benzenepropanamide
EINECS	Contact for details

Quality Control

Our Ronacaleret is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.