Description

Methyl 2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanoate is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic ester structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its unique bromo-fluoro substitution pattern enables precise molecular modifications. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated aromatic core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its stable, substituted phenyl group.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and Industrial R&D: Used in research laboratories for method development and exploring new chemical reactions involving ester and aryl halide functionalities.

Basic Information

Product Name	Methyl 2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanoate
CAS No.	749929-35-9
Molecular Formula	C11H12BrFO2
Molecular Weight	275.12 g/mol
Synonyms	2-(4-Bromo-2-fluorophenyl)-2-methylpropanoic acid methyl ester; Methyl α-(4-bromo-2-fluorophenyl)isobutyrate; 4-Bromo-2-fluoro-α,α-dimethylbenzeneacetic acid methyl ester; Methyl 2-methyl-2-(4-bromo-2-fluorophenyl)propanoate; Propanoic acid, 2-(4-bromo-2-fluorophenyl)-2-methyl-, methyl ester; 749929-35-9; Methyl 2-(4-bromo-2-fluorophenyl)-2-methylpropionate
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Bromo-2-Fluorophenyl)-2-Methylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light) as indicated by its chemical properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.