Description

Benzene, 1-Ethynyl-4-Fluoro-2-(Methoxymethoxy)- (9Ci) is a specialized fluorinated aromatic building block featuring both an ethynyl and a protected hydroxyl group. This unique molecular architecture makes it a high-value intermediate for constructing complex organic frameworks in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its conjugated ethynyl group.
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate for Sonogashira and other palladium-catalyzed coupling reactions to create complex molecular architectures.
• Chemical Biology Probes: Utilized in the synthesis of fluorescent tags and molecular probes for diagnostic and bio-imaging applications.
• Academic & Industrial R&D: A versatile building block for exploratory chemistry in both university laboratories and corporate research centers.

Basic Information

Item	Detail
Product Name	Benzene, 1-Ethynyl-4-Fluoro-2-(Methoxymethoxy)- (9Ci)
CAS No.	749874-25-7
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	1-Ethynyl-4-fluoro-2-(methoxymethoxy)benzene; 4-Fluoro-2-(methoxymethoxy)phenylacetylene; 2-(Methoxymethoxy)-4-fluorophenylacetylene; 1-Fluoro-4-[(methoxymethoxy)methyl]ethynylbenzene (alternative); MOM-protected 4-fluoro-2-hydroxy phenylacetylene derivative; Fluorinated phenylacetylene MOM ether; [749874-25-7]
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-Ethynyl-4-Fluoro-2-(Methoxymethoxy)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.