Description

2-Fluoroquinoline-3-Boronic Acid is a high-value boronic acid derivative and a key synthetic intermediate in modern organic chemistry. Its molecular structure, featuring both a quinoline core and a boronic acid functional group, makes it an essential building block for constructing complex molecules via cross-coupling reactions. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used to create advanced active ingredients for crop protection products, leveraging the fluorinated quinoline scaffold.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, where the quinoline moiety contributes to charge transport properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorescent probes and molecular tags for biological imaging and diagnostic applications.
• Catalyst Ligand Synthesis: The boronic acid group allows for incorporation into complex ligand systems for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for methodological development in synthetic organic chemistry within university and CRO laboratories.

Basic Information

Product Name	2-Fluoroquinoline-3-Boronic Acid
CAS No.	745784-10-5
Molecular Formula	C9H7BBrFNO2 (Pinacol ester form common)
Molecular Weight	Contact for details
Synonyms	2-Fluoro-3-quinolineboronic Acid; (2-Fluoroquinolin-3-yl)boronic Acid; 3-Borono-2-fluoroquinoline; Quinoline, 2-fluoro-3-borono-; 2-Fluoroquinoline-3-boronic Acid Pinacol Ester; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline; B-(2-Fluoro-3-quinolinyl)boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Fluoroquinoline-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.