Description

Betamethasone B-D-Glucuronide is a key conjugated metabolite of the potent glucocorticoid betamethasone. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical standards. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) involved in steroid analysis and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the qualitative and quantitative analysis of betamethasone and its metabolites in biological matrices.
• Metabolite Identification & Pharmacokinetic Studies: Essential for investigating the metabolic pathways, clearance rates, and bioavailability of betamethasone in preclinical and clinical research.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and doping control.
• Toxicology and Safety Assessment: Employed in studies to understand the distribution, excretion, and long-term safety profile of betamethasone.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control laboratories of steroid API and finished product manufacturers.

Basic Information

Product Name	Betamethasone B-D-Glucuronide
CAS No.	744161-79-3
Molecular Formula	C28H37FO12
Molecular Weight	584.59 g/mol
Synonyms	Betamethasone 17-Glucuronide; Betamethasone D-Glucuronide; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-(β-D-glucopyranosiduronic acid); Betamethasone β-D-Glucuronide; Betamethasone Glucuronide Conjugate
EINECS	Contact for details

Quality Control

Our Betamethasone B-D-Glucuronide is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.