Description

tert-Butyl 4-(2-Chlorobenzyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the creation of new active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its modifiable piperazine core and protective tert-butoxycarbonyl (Boc) group.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Agrochemical Development: Employed in the research and production of advanced crop protection agents and pesticides.
• Ligand and Catalyst Preparation: Utilized for constructing specialized ligands for metal catalysis or as a component in organocatalysts.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	tert-Butyl 4-(2-Chlorobenzyl)Piperazine-1-Carboxylate
CAS No.	741626-47-1
Molecular Formula	C16H23ClN2O2
Molecular Weight	310.82 g/mol
Synonyms	1-Boc-4-(2-Chlorobenzyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-chlorobenzyl)piperazine; 4-(2-Chlorobenzyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-chlorophenyl)methyl-1-piperazinecarboxylate; N-Boc-4-(2-Chlorobenzyl)piperazine; 1-N-Boc-4-(2-Chlorobenzyl)piperazine; Boc-2-Cl-Bn-Piperazine; Piperazine, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(2-chlorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Chlorobenzyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications requiring cGMP starting materials and compliance with REACH regulations for the global market.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.