Description

2-(Di-tert-Butylphosphino)-1-Phenylindole is a specialized organophosphorus ligand used in advanced catalytic processes. This compound matters for its role in facilitating highly selective cross-coupling and hydrogenation reactions, which are critical for constructing complex molecular architectures. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing new synthetic routes and optimizing production efficiency.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• For catalyst development in asymmetric hydrogenation and other chiral inductions.
• In academic and industrial research for novel synthetic methodology development.
• As a key intermediate or precursor in the synthesis of more complex catalytic systems.
• For process chemistry optimization in pharmaceutical active ingredient (API) manufacturing.
• In the synthesis of specialty polymers and advanced materials requiring precise metal coordination.

Basic Information

Product Name	2-(Di-tert-Butylphosphino)-1-Phenylindole
CAS No.	740815-37-6
Molecular Formula	C22H28NP
Molecular Weight	337.44 g/mol
Synonyms	2-(Di-tert-butylphosphanyl)-1-phenyl-1H-indole; 1-Phenyl-2-(di-tert-butylphosphino)indole; 2-(Di-tert-butylphosphino)-1-phenylindole; Di-tert-butyl(1-phenyl-1H-indol-2-yl)phosphine; P(t-Bu)2-Phenylindole Ligand; Buchwald-type Ligand; JohnPhos Derivative; Phosphinoindole Ligand
EINECS	Contact for details

Quality Control

Our 2-(Di-tert-Butylphosphino)-1-Phenylindole is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.