Description

4-Ethynylpiperidine is a versatile and highly reactive organic building block featuring both a piperidine ring and a terminal alkyne functional group. This unique bifunctional structure makes it a critical intermediate for constructing complex molecular architectures in advanced chemical synthesis. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, drug discovery, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in creating novel piperidine-based compounds with potential neurological or therapeutic activity.
• Click Chemistry Reagent: The terminal alkyne group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition (click chemistry) reactions with azides to form triazole linkages, useful in bioconjugation and polymer science.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis, including those for transition metal-catalyzed cross-coupling reactions.
• Agrochemical Research: Serves as a building block for synthesizing new candidates for herbicides, fungicides, and insecticides.
• Material Science: Incorporated into monomers or cross-linkers for the synthesis of advanced polymers with tailored properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological systems and enzyme activity via click chemistry tagging.

Basic Information

Product Name	4-Ethynylpiperidine
CAS No.	738577-08-7
Molecular Formula	C7H11N
Molecular Weight	109.17 g/mol
Synonyms	4-Ethynylpiperidine; 4-Piperidinylacetylene; 1-(Piperidin-4-yl)ethyne; 4-(Ethynyl)piperidine; Piperidine, 4-ethynyl-; 4-Ethynyl-piperidine; 4-Ethynylpiperidine hydrochloride (salt forms); 1-Aza-4-ethynylbicyclo[2.2.2]octane (related bicyclic analog)
EINECS	Contact for details

Quality Control

Our 4-Ethynylpiperidine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Standard Grade)
Purity (HPLC/GC)	≥ 98% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.